Hi there,
So, it should be fine for a short cable but beware!
1. What’s really on that B2B connector?
On the XIAO ESP32S3 Sense, the B2B isn’t just “a few GPIOs” – it carries:
- Parallel camera bus (DVP): D0–D9, PCLK, VSYNC, HREF
- Camera I²C (SCL/SDA)
- SD card SPI (CS, SCK, MISO, MOSI)
- PDM microphone (CLK, DATA)
- Power + ground
Those camera and SD signals run in the tens of MHz range (e.g. 20–40 MHz clock edges). The board and connector were designed assuming the Sense board is directly stacked – essentially zero extra trace length.
So electrically, that B2B is a high-speed parallel bus, not a low-speed “TTL I/O header”.
Your out on the Bleeding edge here so expect some cuts, 
You can probably order a custom ribbon cable, but AFAIK nothing like it exists on seeeds website.
HTH
GL 
PJ 
Check out the MORE I/O thread for the PCB I made for it.
