Yes, mixing many things. I am learning.
Regarding LDO: In RadioLib, there is a choice between LDO and DC-DC. What is the right choice?
Regarding nRF54: It cannot go below -20°C if I remember. In freezers -24 to -18°C max. Outdoor down to -35 sometimes.
According to the nRF54LM20A datasheet, the operating temperature range is -40 to 85 degrees Celsius.
With a simple LoRa based battery operated “-40°C freezer temperature project”, I’d probably go for the Seeed Wio-E5 and flash it (over SWD ->STLink/JLink) using the appropriate (STM32 or Arduino) code and libs.
Use a Lithium Manganese Dioxide battery and 1.8V LDO. Add any essential sensors using I2C.
Battery → LDO → Wio-E5 ↔ Sensors
Hi there,
So completely ignoring the actual hardware the OP is trying to work through and essentially replying, “Just throw all that out, buy a Wio-E5, flash it with an ST-Link, and build a totally different project.” It doesn’t answer actual confusion about the LDO dropout, peak currents, or RadioLib internals.
SO staying on point , I know it’s a FAT topic for some. but to your question about the RadioLib LDO vs. DC-DC setting:
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RadioLib’s Setting is purely for the internal SX1262 core: It controls the transceiver’s internal step-down regulator (pin REG_MODE powering the RF core from VDD), not the board’s power rail.
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DC-DC is the right choice: Setting setRegulatorLDO() burns extra current as heat. Setting setRegulatorDCDC() (which the Seeed LoRa expansion/breakout boards wire for) drops the RX/TX current draw significantly—roughly cutting receive current in half (~4.6 mA vs ~8.4 mA) and shaving crucial milliamps off peak TX.
HTH
GL
PJ 
You know " No Pain NO Gain! 
Further to this Simple Single CPU coin cell battery based, low power option using a Seeed Wio-E5, if I wanted to test and prove the “theory” with minimal expertise or complexity, I’d use a Seeed Grove Wio-E5 module.
To achieve lower battery voltage and power consumption, I’d replace the AP7333-33SRG LDO with a Torex XC6206P182MR-G (which matches the pinout). I’d also add 2x 47uF Tantalum-Polymer Capacitors for power support (Coin Cells and LDO).
Total cost for Wio, LDO and Caps ~USD20.