I2c slave and interrupt at pin D9 and D10


I am usion the XIAO as a “keyboard controller” which is read out as a i2c slave via Wire.onRequest from a master controller on the SDA and SCL pins (D4 and D5).
On the pin 6 i have an analog input configured…all other pins are configured as digital input with interrupt for positive/negative edge (CHANGE).
My problem is:
It seems that when i activate the i2c and i request data from the XIAO the interrupt on pin D10 gets fired all the time. Is there a restriction concerning i2c and interrupts (pin D10)?

Thank you for your help