XIAO ESP32S3 interfacing with Grove - Wio-E5

Ok, So what about the Wire.begin before your begin for serial ports?

u8x8.begin();                               // Initialize OLED display
    u8x8.setFlipMode(1);
    u8x8.setFont(u8x8_font_chroma48medium8_r);
**Wire.begin();**
    Serial.begin(115200);                       // Initialize serial communication
    pinMode(LED_BUILTIN, OUTPUT);               // Set LED pin as output
    digitalWrite(LED_BUILTIN, HIGH);            // Turn off LED