Hi There ajs00,
So from what I gleaned the interrupt also controls the PIN? and resets it?
also what’s the rs-485 a terminal port ie.HALF duplex (2-wire) the timing is tight at Higher baud rates, You may want to add some delay in looking for the line turn-around or data.
So are You wired
| PC<--USB-->LoRa-E5 <RS-485>----<RS-485>LoRa-E5 <UART> (message TTL) ? or 3.3v
It would make sense that code and configured for the other jumper setting (TX/RX) the fullduplex is built in.
I like these boards but don’t have one (it’s on the list, LOL)
HTH
GL 
PJ