Problem with Lora-e5 module when integrating into a custom board

Hi there

I am using Lora-e5 module in my custom board.
I am using STM32CubeIDE and third party ST-Link v2 debugger.
My custom board is battery powered.
The debugger connected over the SWD.
I have successfully perform some basic IO operations.
The issue was discovered while trying to debug the LoRaWan-E5-Node application.
As soon as I start a debug session it fails and the module becomes unreachable.
It looks like the module is getting dead because it can’t be connected even via STM32CubeProgrammer.
Please be informed that I have integrated RF matching circuit by using the schematic and the BOM list from the sources.

Could you please provide me with further instructions
Best Regards