It is very likely that it will not. The sector size has been increased from 512 bytes to 4kB, which has caused a few changes on the application side as well.
Too bad that the developers of the DSO Quad do not interact with the community - it would have been a trivial matter to preserve the API given to applications. In fact, I could do that in AlterBIOS, but I’m afraid it would break the official APP…