XIAO RP2350 with Micropython v1.24.0-preview.201.g269a0e0e1 does not start main.py

Instead of changing directory temporarily, mount the SD card to /sd but do not change to it at all inside boot.py. Modify your boot.py to avoid os.chdir entirely:

def mount_sd():
    sd = SDCard(sd_spi, machine.Pin(PIN_SD_CS))
    try:
        os.mount(sd, "/sd")
        print("SDCard mounted")
        return True
    except OSError as exc:
        print("mounting SDCard failed")
        sys.print_exception(exc)
        return False

if __name__ == '__main__':
    mount_sd()

Also make sure boot.py completes quickly — any delays in boot.py (e.g., slow SD init) might interfere with main.py execution on some boards.